1958 yılında Burdur'da doğdu. Ege Tıp fakültesinde 5 yıl okuduktan sonra 1982 yılında GATA Tıp Fakültesinden birincilikle mezun oldu. 1990 yılında İç Hastalıkları uzmanı, 1992 yılında Endokrinoloji Uzmanı oldu. 1994 yılında doçent 2003 yılında profesör oldu. 1986 yılında Almanya da çalıştı. 1992-1993 yıllarında Amerika'da Chicago Üniversitesi Endokrin Tiroid Bölümünde çalıştı. 2003-2008 yılları arasında GATA Haydarpaşa Eğitim Hastanesi Endokrinoloji ve Metabolizma kliniği direktörlüğü yaptı. 2008 Ağustos ayında kendi isteği ile emekli oldu. Halen sadece muayenehanesinde serbest hekimlik yapmaktadır. İngilizce ve Almanca bilir.
ALDIGI ODULLER
1. Turk Diabet Cemiyeti Prof. Celal Oker Bilim Odulu (1995) 2. Bayindir Tip Merkezi Bilim Tesvik Odulu (1997) 3. TUBITAK Bilim Tesvik Odulu (1998) 4. Endokrinoloji ve Metabolizma Kongresi En Iyi Sozel Bildiri Odulu (1998) 5. GATA 100. Yil Ulusal Bilim Yarismasi ikinciligi odulu (1998) 6. GATA 100. Yil TSK Saglik personeli Bilim yarismasi ucuncusu (1998) 7. Endokrinoloji ve Metabolizma Kongresi en iyi sozel bildiri odulu (1999) 8. Roche Bilimsel Arastirma Endokrinoloji Bilim Odulu Birincisi (2000) 9. 2. Ulusal Ic Hastaliklari Kongresi En iyi bildiri ucunculuk odulu (2000) 10. GATA 2000-2001 yili Dahili Bilimler Arastirma Makalesi 2. ve 4.cusu 11. Servier Diabet Proje Yarismasi Proje Destek Odulu (2000) 12. Metabolik Sendrom X Bilimsel Arastirma Yarismasi Birinciligi (2000) 13. Turk Diabet Vakfi Diabet Arastirma Birincilik Odulu (2001) 14. TUBITAK Turkiye Tip Arastirma Odulu (2001) 15. Turk Diabet Vakfi En iyi Bilimsel yayin Birinciligi (2002) 16. GATA en iyi yayin ikinciligi (2002) 17. Bayindir Tip Merkezi Bilim Odulu (2003) 18. Istanbul Universitesi Bilim Odulu (2003) 19. Ulusal Endokrinoloji Kongresi En iyi 3. Poster Odulu (2006) 20. 5-7 Ekim 2006 gunleri arasinda Las Vegas, A.B.D.’de yapilan 4 ncu Dunya Insulin Rezistans Sendromu Kongresi’nde en iyi poster ikincilik odulu almistir
HAKEMLIK YAPTIGI DERGILER VE KURULUSLAR 1. J Clin Endocrinol Metab (A.B.D.) 2. Endocrinology (A.B.D) 3. Israel Academy of Science (Israil) 4. Diabetologia (Avrupa) 5. Clinical Laboratory Medicine (Almanya) 6. Int. J. Obesity (A.B.D) 7. Turkish Medical Sciences (TUBITAK) 8. Turkish Journal of Endocrinology and Metabolism 9. Gulhane Tip Dergisi 10. Ankara Universitesi Tip Fakultesi Dergisi 11. TUBITAK Saglik Bilimleri Arastirma Grubu Proje Danismanligi 12. GATA Arastirma Merkezi Proje Danismanligi 13. Nobel Medicus Dergisi 14. Guraba Hastanesi Dergisi
YURTDISINDA VERDIGI KONFERANSLAR 1. Pastor Enstitusunde ‘’Euroconferans on Obesity’’ de ‘’Obesity and Reproduction’’ isimli konferans (Kasim, 1999) (Paris, Fransa) 2. 5. Avrupa Endokrinoloji Kongresinde ‘’ Leptin Deficiency and Resistance’’ konulu konferans (Torino, Italya, 9 Haziran 2001)
YURTDISI YAYINLARINA ATIF SAYISI
Mayis 2009 tarihi itibariyle yurtdisi yayinlarina 2100 atif yapilmistir
YURDISINDA VERDIGI KONFERANSLAR: 1. Paris Pastor Enstitusunde Avrupa Obezite Sempozyumunda ‘’Obezite ve Reproduktif Sistem’’ isimli konferans (Kasim ,1999) 2. 9 Haziran 2001 tarihinde Italya Torino’da yapilan 5. Avrupa Endokrin Kongresinde ‘Leptin yetmezligi ve direnci’’ isimli bir konferans vermistir.. 3. 12. Balkan Endokrinoloji Kongresinde (Mayis 21-25, 2003 Selanik,Yunanistan) ‘’ Human Leptin Deficiency’’ konulu bir konferans vermistir.
YAPTIGI EK GOREVLER:
1. 1995-200 tarihleri arasinda GATA Arastirma Merkezi Tibbi Arastirma Bolum Baskanligi 2. Gulhane Tip Dergisi Yardimci Editorluk (1995-2000). KENDI YAZDIGI KITAPLAR 1. ‘’Obezite Tani ve Tedavisi’’ GATA Basimevi, 2003, Ankara 2. ‘’Tiroid Hastaliklarinda Tani ve Tedavi’’ GATA Basimevi, 2003, Ankara 3. Tiroid Kanserleri, Ayin kitabi 2003, GATA Basimevi,Ankara 4. Noduler Guatr, Ayin Kitabi , 2003, GATA Basimevi,Ankara 5. Tirotoksikoz” Ayin Kitabi Nisan 2004, GATA Basimevi,Ankara 6. Dogru Beslen Formda Kal, Epsilon Yayinevi, 2004, Istanbul 7. Hipotiroidizm Tani ve Tedavisi-GATA Basimevi , Nisan 2005 Ayin Kitabi 8. Tiroid Hastaliklarina Guncel Yaklasim. Epsilon Yayinevi, 2005, Istanbul 9. Tiroit Hakkinda Bilmeniz Gereken Her Sey, Epsilon Yayinevi, 2005, Istanbul 10. Diyabet Hakkinda Bilmeniz Gereken Her Sey, Epsilon Yayinevi, 2006 11. G.I. Diyeti, Erko yayincilik, 2007 Istanbul 12. 99 Sayfada Kilo Yonetimi ve Bilimsel Zayiflama,Is bankasi yayini, 2007 13. Vitamin Mineral ve Bitkisel Urun Rehberi, Gurer yayinlari, 2008 14. 99 Sayfada Tiroid Hastaliklari, Is bankasi yayini, 2008 15. Diyabetle Kaliteli Yasam Rehberi, Gurer yayinlari, 2009 16. Guatr ve Tiroid Rehberi, Gurer yayinlari, 2010 17. NATUREL ZAYIFLAMA-METABOLIZMA DİYETİ, HAYY KİTAP 2010 18. Tiroid Tani ve Tedavi Baskida
19. Endokrinoloji, Baskida
20. Hormonlar ve Siz Baskıda
YURTDISINDA YAYINLANAN KITAP BOLUMU 1. Editorlugunu Bolis CL, Licinio J, Govoni S’ nin yaptigi ‘’The Autonomic Nervous System’’ isimli 2003 yilinda Marcel Dekker Inc. tarafindan A.B.D’de basilmis olan kitabin ‘’Autonomic Nervous System-Leptin Interaction’’ isimli bolumunu Bulent Yildiz, Ma-Li Wong ve Julio Licinio ile beraber yazmistir.
EDITORLUGUNU YAPTIGI KITAPLAR 1. Tiroit Hastaliklarina Guncel Yaklasim, Epsilon Yayinevi, 2005, Istanbul 2. Endokrinoloji-Metabolizma Diabet, Istanbul Medikal Yayincilik, 2006, Istanbul 3. Tip 2 Diyabetin Tibbi Tedavisi (ADA Yayini) Turkce Ceviri Editoru.2004
YURTICINDE YAYINLANAN KITAP BOLUMLERI 1. Ilicin, Unal, Biberoglu, Akalin, ve Suleymanlar’in editorlugunu yaptigi TEMEL IC HASTALIKLARI kitabinin (Gunes Kitabevi Ltd. Sti.., Ankara, 1996) HIPERLIPOPROTEINEMILER ve SEKS FARKLILASMA BOZUKLUKLARI ( sayfa 1500-1516) konularini yazmistir. 2. Editorlugunu Prof. Dr. Olcay Gedik’in yaptigi ‘Mezuniyet Sonrasi Diabetes Mellitus Kursu’ kitabinin ‘Beta3 adrenerjik reseptor gen polimorfizmi ve NIDDM’ konusunu yazmistir.1997. 3. Editorlugunu Yalcin Aral’in yaptigi ENDOKRINOLOJI VE METABOLIZMA HASTALIKLARINDA TEMEL TEDAVI KITABI’nin (Bilimsel Tip Yayinevi, 1998) TIROID TUMORLERI, TIROID NODULLERI ve TIROID HORMON REZISTANSI SENDROMLARI bolumlerini yazmistir. 4. Editorlugunu Prof.Dr. Husrev Hatemi, Prof . Dr. Taylan Kabalak ve Prof.Dr Gurbuz Erdogan’in in yaptigi ‘’ Klinik Tiroid ‘’ kitabinin ‘Hashimoto Tiroiditi ‘ bolumunu yazmistir. Kelebek Matbaacilik, Aralik 2001. 5. Editorlugunu Prof. Dr. Olcay Gedik’in yaptigi ‘ Endokrinoloji ve Metabolizma Hastaliklari Kurs Kitabi’ nin ‘Iyi Diferansiye Tiroid Karsinomalariinin Etiyopatogenezinde Onkogenler ve Tumor Supressor Genlerin Rolu’ ve ‘AIDS’te Adrenal ve Gonad’ bolumlarini yazmistir. 1998. 6. Endokrin Bolum Editorlugunu Prof. Dr. Olcay Gedik’in yaptigi ve yakinda basilacak olan Ic Hastaliklari Kitabinin ‘’Yeme davranisi bozukluklari’’ bolumunu yazmistir. 7. Tiroid Hormon Rezistansi, Kitap Bolumu. Kologlu Endokrinoloji Temel Klinik 2.Baski MN Medikal ve Nobel. 2005
YAYINLAR LISTESI (Kronolojik sira) YURTDISI YAYINLAR 1. *Ozata M., Suzuki S., Miyamoto T., Lui RT., Fierro-Renoy F., DeGroot LJ: Serum thyroglobulin in the follow-up of patients with treated differentiated thyroid cancer. J Clin Endocrinol Metab. 79:98-105, 1994. 2. *Liu RT., Suzuki S., Miyamoto T., Takeda T., Ozata M., DeGroot LJ.: The dominant negative effect of thyroid hormone receptor splicing variant 2 does not require binding to a thyroid response element. Molecular Endocrinology. 9:86-95,1995. 3. *Ozata M., Kurt I., Azal O., Bolu E., Corakci A., Beyhan Z., Karaca L., Gundogan MA.:Can we use plasma fibronectin levels as a marker for early diabetic nephropathy. Endocrine Journal. 42:301-305, 1995. 4. *Ozata M., Ozkardes A., Corakci A., Gundogan MA.:Subclinical hypothyroidism does not lead to alterations either in peripheral nerves or in brainstem auditory evoked potentials (BAEPs). Thyroid. 5:201-205,1995. 5. *Ozata M., Bayhan H., Bingol N, Dundar S., Beyhan Z., Corakci A., Gundogan MA.:Sequential changes in serum TPO following radioiodine therapy of patients witrh differentiated thyroid carcinoma. J Clin Endocrinol Metab. 80:3634-3638,1995. 6. *Ozata M., Suzuki S, Takeda T., Malkin DG, Miyamoto T., Liu R-T., Suzuki N., Silverberg JDH, Daneman D., DeGroot LJ.: Functional analysis of a proline to serine mutation in codon 453 of the thyroid hormone receptor 1 gene. J Clin Endocrinol Metab. 80: 3239-3245,1995. 7. *Ozata M., Bulur M., Bingol N., Beyhan Z., Corakci A., Bolu E., Gundogan MA.:Daytime plasma melatonin levels in male hypogonadism. J Clin Endocrinol Metab. 81:1877-1881.1996. 8. *Yildiz O., Bolu E., Deniz G., Senoz S., Simsek A., Ozata M., Gundogan N, Gundogan MA: Effects of dexfenfluaramine on glucose drinking and glucose- conditioned flavour preferences in rats: Taste versus post-ingestive conditioning. Pharmacol Res. 33:41-46, 1996. 9. *Yildirimkaya M., Bilgi C., Ozata M., Nazaroglu NK, Gundogan MA,Kutluay T., Karaca L.: Biological variation of serum lipids and lipoproteins in patients with clinically well controlled non insulin dependent diabetes mellitus. Endocrine Journal. 43:345-351, 1996. 10. *Ozata M., Bolu E., Sengul A., Tasar M, Beyhan Z, Corakci A., Gundogan MA.: Effects of octreotide treatment on Graves’ ophthalmopathy and circulating sICAM-1 levels. Thyroid. 6:283-288, 1996. 11. *Ozata M., Yildirimkaya M., Bulur M., Yilmaz K., Bolu E., Corakci A., Gundogan MA.: Effects of gonadotropin and testosterone treatments on lipoproten (a), HDL particles and other lipoprotein levels in male hypogonadism. J Clin Endocrinol Metab. 81: 3372-3378, 1996. 12. *Ozata M., Ozkardes A., Bulur M., Beyhan Z., Corakci A., Yardim M, Gundogan MA.: Central and peripheral neural responses in males with idiopathic hypogonadotropic hypogonadism. J Endocrinol Invest. 19: 449-454, 1996. 13. *Ozata M., Bolu E., Sengul A., Altinsoy HI, Turan M., Corakci A., Gundogan MA.:Soluble intercellular adhesion molecule-1 concentrations in patients with subacute thyroiditis and in patients with Graves’ disease with or without ophthalmopathy. Endocrine Journal. 43: 517-525, 1996. 14. *Yildiz O., Ozata M., Ozkardes A., Deniz G., Yildirimkaya M.,Corakci A., Yardim M, Gundogan MA.: Comparison of the effects of aminoguanidine and L-carnitine treatments on somatosensory evoked potentials in alloxan- diabetic rats. NS’s Arch Pharmacol. 354: 526-531, 1996. 15. *Ozkardes, A., Ozata M., Beyhan Z., Corakci A, Vural O, Yardim M, Gundogan MA.:Acute hypothyroidism leads to reversible alterations in central nervous system as revealed by somatosensory evoked potentials. Electroencephalography and Clinical Neurophsiology 100:500-504, 1996. 16. *Ozata M., Ozkardes A., Dolu H, Corakci A., Yardim M, Gundoðan MA.:Evaluation of central motor conduction in hypothyroid and Hyperthyroid patients. J Endocrinol Invest. 19:449-454, 1996. 17. *Beyan C., Ural AU, Cetin T, Ozata M., Yalcin A.: Acute promyelocytic leukemia in the course of acromegaly. Endocrine Journal.43:565-568, 1996. 18. *Yildirimkaya M., Ozata M, Yilmaz K, Kilinc C, Gundogan MA, Kutluay T: Lp(a) concentration in subclinical hypothyroidism before and after levo-thyroxine therapy. Endocrine Journal. 43:731-736,1996. 19. *Ozata M, Gundogan MA.: Early morning melatonin levels in hypogonadal men-Author’s response. J Clin Endocrinol Metab. 81:4181-4182, 1996. 20. *Yildiz O., Ozata M., Ozkardes A., Corakci A., Gundogan NU, Gundogan MA.: L-carnitine treatment improves auditory evoked potentials in diabetic rats. NeuroReport. 7(18):2957-2959,1996. 21. *Ozata M., Kurt I., Serdar M., Onde ME, Corakci A.,Gundogan MA.: Biochemichal composition of benign thyroid cyst fluid. Biol Trace Elem Res. 57:9-17, 1997. 22. *Ozata M., Tayfun C, Kurtaran K., Yetkin I, Beyhan Z., Caglayan S, Alemdaroglu A, Corakci A., Gundogan MA.:Magnetic resonance imaging of posterior pituitary for evaluation of the neurohypophyseal function in idiopathic and autosomal dominant neurohypophyseal diabetes insipidus. European Radiology. 7:1098-1102, 1997. 23. *Ozata M, Ozturk E, Narin Y, Tayfun C, Azal O, Beyhan Z, Corakci A, Bayhan H, Gundogan MA.: A case of thyrotropin secreting pituitary adenoma with normal TSH-. Thyroid. 6:441-447,1997. 24. *Ozata M., Ozkardes A.,Corakci A., Beyhan Z., Gundogan M.A.:Event related brain potentials in hypothyroidism. Endocrine Practice 3:349--352,1997. 25. Ozata M.,Ozkardes A., Beyhan Z, Corakci A, Gundogan MA.:Central and peripheral neural responses in acromegaly. Endocrine Practice.3:118-122, 1997. 26. *Ozata M., Odabasi Z, Musabak U., Corakci A., Gundogan M.A.: A case of Addison’s disease associated with Lambert-Eaton myastenic syndrome. J. Endocrinol Invest. 20:338-341, 1997. 27. *Ozata M, Bulur M, Beyhan Z, Sengul A, Saglam M, Turan M, Corakci A, , Gundogan MA.: Effects of gonadotropine and testosterone treatments on prostate volume and serum prostate specific antigen levels in male hypogonadism. Endocr J, 44: 719-724 ,1997. 28. Ozata M, Ozkardes A, Odabasi Z, Corakci A, Gundogan MA.: Auditory event-related brain potentials in hyperthyroidism. Acta Neurol Belg. 97:228-232, 1997. 29. *Ataergin S., Ozata M., Karaeren H., Salk M., Corakci A., Gundogan M.A.: A case of Noonan’s sydrome with numerous cardiac abnormalities. Endocrine Practice , 4:33-36, 1998. 30. *Strobel A., Issad T., Camoin L., Ozata M., Strosberg A.D. A Leptin missense mutation associated with hypogonadism and morbid obesity. Nature Genetics, 18:213-215 ,1998 31. *Ozata M, Yildirimkaya M, Yilmaz K, Beyhan Z, Corakci A, Kutluay T, Gundogan MA: The effect of thyroid status on serum apolipoprotein A-I containing lipoprotein particles. Horm Metab Res. ,30:217-221,1998. 32. *Ozata M, Beyhan Z.: Effects of testosterone treatment on plasma melatonin levels in male hypogonadism. Clinical Endocrinology,48:669-670,1998. 33. *Ozata M., Ozisik G., Bingol N.: The effects of thyroid status on plasma leptin levels in women. J.Endocrinol Invest ,21:337-341,1998. 34. *Ozata M,Ozisik G., Caglayan S., Yesilova S., Bingol N., Saglam M., Turan M., Beyhan Z.: Effects of gonadotropin and testosterone treatments on plasma leptin levels in male patients with idiopathic hypogonadotropic hypogonadism and Klinefelter’s syndrome. Horm. Metab. Res., 30:217-221, 1998. 35. *Issad T, Strobel A, camoin L, Ozata M, Strosberg AD: Leptin and puberty in humans:hypothesis of the critical adipose mass revisited. Diabetes Metab., 24:376-378, 1998 36. *Uckaya G, Ozata M, Sonmez A, Kinalp C , Eyileten T , Bingol N, Koc B, Kocabalkan F, Ozdemir I.C. Plasma Leptin Levels Strongly Correlates with Plasma Renin Activity in Patients with Essential Hypertension. Horm Metab Res 31:435-438, 1999. 37. *Ozata M, Uckaya G, Beyhan Z, Ozdemir IC. Plasma leptin levels in male patients with idiopathic central diabetes insipidus. J Endocrinol Invest 22:451-454, 1999. 38. *Ozata M, Odabasi Z, Caglayan S, Beyhan Z, Vural O, Ozdemir I.C. Event-related brain potentials in male hypogonadism. J Endocrinol Invest 22:508-513, 1999. 39. *Ozata M, Salk M, Aydin, Sayin S, Oktenli C, Beyhan Z, Isimer A, Ozdemir IC. Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. Biol Trace Elem Res 69:211-216, 1999. 40. Mergen H, Oner C, Ozata M, Oner R. Screening for mitochondrial gene mutations in patients with diabetes mellitus in Turkey. Balkan journal of medical genetics. 2: 17-20, 1999. 41. *Gul H, Odabasi Z, Yildiz O, Ozata M, Deniz G, Vural O, Isimer A. Beneficial effect of thyrotropin-releasing hormone on neuropathy in diabetic rats. Diabetes Res Clin Prac. 44:93-100, 1999. 42. *Ozata M, Ozdemir IC, Licinio J. Multipl endocrine defects, decreased sympathetic tone, and immune system dysfunction in patients with a missense human leptin gene muatation: new targets for leptin action and spontaneous correction of leptin- mediated defects. J Clinical Endocrinol Metab. 84:3686-3695, 1999. 43. *Yesilova Z, Ozata M, Kocar IH, Pekel A, Sengul A, Ozdemir IC. The effects of gonadotropin treatment on the immunological features of male patients with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 85:66-70, 2000. 44. *Odabasi E, Ozata M, Turan M, Yonem A, Cakir B, Bingol N, Kutlu M, Ozdemir IC. Plasma leptin concentrations in postmenopausal women with osteoporosis. Eur J Endocrinol. 142:170-173, 2000. 45. *Uckaya G, Ozata M, Sonmez A, Eyileten T, Bingol N, Kocabalkan F, Ozdemir IC. Is leptin associated with hypertensive retinopathy? J Clin Endocrinol Metab, 85: 683-687, 2000. 46. *Uckaya G, Ozata M, Bayraktar Z, Bingol N, Ozdemir IC. Is leptin associated with diabetic retinopathy? Diabetes Care 23:371-376,2000. 47. *Proenza AM, Poissonnet CM, Ozata M, Ozen S, Guran S, Palou A, Strosberg AD. Association of sets of alleles of genes encoding beta3adrenoreceptor, uncoupling protein 1 and lipoprotein lipase with increased risk of metabolic complications in obesity. International Journal of Obesity, 24:93-100, 2000. 48. *Ozata M, Uckaya G, Aydin A, Isimer A, Ozdemir IC. Defective antioxidant defense system in patients with a human leptin gene mutation. Horm Metab Res 32:269-272, 2000. 49. *Gul D, Ozata M, Mergen H, Odabasi Z, Mergen M. Woodhouse and Sakati syndrome (MIM 241080): report of a new patient. Clin Dysmorphol. 2000 Apr;9 (2):123-5. 50. *Kocar IH, Yesilova Z, Ozata M, Turan M, Sengul A, Ozdemir IC. The effects of testosterone treatment on immunological features of patients with Klinefelter’s syndrome. Clin Exp Immunol.121:448-452, 2000. 51. Ozata M, Yesilova Z, Saglam M, Tunca Y. A case of Klinefelter’s syndrome associated with unilateral renal aplasia. Med Sci Monit.6:1000-1002, 2000. 52. *Toprak S, Yonem A, Cakir B, Guler S, Azal O, Ozata M, Corakci A. Insulin resistance in nonobese patients with polycystic ovary syndrome. Horm Res. 55:65-70,2001 53. *Caglayan S, Ozata M, Ozisik G, Turam M,Bolu E, Okten C, Gul D, Erbil K, Ozdemir IC. Plasma Melatonin concentrations before and during testosterone treatment: relation with hepatic indolamin metabolism and sympathoadrenal activity. J Clin Endocrinol Metab. 86:, 2001. 54. Ozisik G, Mergen H, Ozata M, Caglayan S, Bolu E, Ozdemir IC,Oner C, Vitamin D receptor gene polymorphism and vertebral bone density in men with idiopathic hypogonadotropic hypogonadism. Med Sci Monit 7:233-237, 2001 55. *Mergen M, Mergen H, Ozata M, Oner R, Oner C. A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. J Clin Endocrinol Metab, 86:3448-3451,2001 56. *Ozata M, Gungor D,Turan M,Ozisik G, Bingol N, Ozgurtas T, Ozdemir IC. Improved gylcemic control increases fasting plasma acylation stimulating protein and decreases leptin concentartion in type 2 diabetic ssubjects. J Clin Endocrinol Metab. 86:3659-3664, 2001. 57. *Mantzoros CS, Ozata M, Negrao AB, Suchard MA, Ziotopoulou M, Caglayan S, Elashoff RM, Cogswell RJ, Negro P, Liberty V, Wong ML,Veldhuis J, Ozdemir IC, Gold PW, Flier JS,Licinio J. Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in health adults and leptin-deficient subjects: Evidence for possible partial TSH regulation by leptin in humans. J Clin Endocrinol Metab.86:3284-3291, 2001. 58. *Ozata M, Avcu F, Durmus O, Yilmaz I, Ozdemir IC, Yalcin A. Leptin does not play a major role in obesity and leptin deficiency. Obes Res. 9:627-630, 2001. 59. Ozata M,Uckaya G, Bolu E, Corapcioglu D, Bingol N, Ozdemir IC. Plasma leptin concentration in patients with Graves’ disease with or without ophthalmopathy. Med Sci Monit. 7:696-700,2001. 60. *Aydin A, Orhan H, Sayal A, Ozata M, Sahin G, Isimer A. Oxidative stress and nitric oxide related parameters in type 2 diabetes mellitus: effects of glycemic control. Clin Biochem. 34:65-70, 2001. 61. Sonmez A, Kisa U, Uckaya G, Eyileten T, Comert B, Koc B, Kocabalkan F, Ozata M. Effects of losartan treatment on T cell activities and plasma leptin concentrations in primary hypertension. Journal ofthe Renin-AngiotensinAldosterone System (JRAAS).2:112-116,2001 62. *Ozata M. Different presentation of bone mass in mice and humans with congenital leptin deficiency. Letter to Editor. J Clin Endocrinol Metab.87:951,2002 63. *Ozata M, Oktenli C, Gulec M, Ozgurtas T,Bulucu F, Caglar K,Bingol N, Vural A, Ozdemir IC. Increased fasting plasma acylation stimulating protein in nephrotic syndrome. J Clin Endocrinol Metab.87:853-858,2002 64. *Rittig S, Siggaard C, Ozata M, Yetkin I, Gregersen N, Pedersen EB, Robertson GL. Autosomal dominant neurohypophyseal diabetes insipidus due to substitution of histidine for thyrosine (2) in the vosopressin moiety of the hormone precursor. J Clin Endocrinol Metab, 87:3351-3355, 2002 65. Arpaci F, Yilmaz MI, Ozet A, Ayta H, Ozturk B, Komurcu S, Ozata M. Low serum leptin level in colon cancer patients without significant weight loss. Tumori, 88:147-149, 2002. 66. *Oktenli C, Yesilova Z, Kocar IH, Musabak U, Ozata M, Inal A, Gul D, Sanisoglu Y. Study of autoimmunity in Klinefelter’s syndrome and idiopathic hypogonadotropic hypogonadism. J Clin Immunol. 22:137-143, 2002-09-04 67. *Ozata M, Durmus O, Yilmaz M, Bolu E, Erdogan M, Ozdemir C. The renin-angiotensin-aldosterone system (RAAS) and its relation with calcium homeostasis in male obesity.Med Sci Monit. 8: CR430-437 68. *Akar A, Orkunoglu E, Sengul A, Ozata M, Gur AR. HLA class II alleles in patients with alopecia areata. Eur J. Dermatol 12 :236-239, 2002. 69. *Ozata M, Mergen M, Oktenli C, Aydin A, Sanisoglu SY, Bolu E, Yilmaz MI, Sayal A, Isimer A, Ozdemir IC. Increased oxidative stress and hypozincemia in male obesity. Clin Biochemistry. 35:627-631,2002. 70. *Kilciler G, Ozata M, Oktenli C, Sanisoglu SY, Bolu E, Bingol N, Kilciler M, Ozdemir IC, Kutlu M.Diurnal leptin secretion is intact in male hypogonadotropic hypogonadism and is not influenced by exogenous gonadotropins. J Clin Endocrinol Metab.87:5023-5029,2002. 71. *Ozata M, Dieuguez C, Casaneuva FF. The inhibition of growth hormone secretion presented in obesity is not mediated by the high leptin levels: A study in human leptin deficiency patients. J Clin Endocrinol Metab. 88:312-316,2003. 72. *Musabak U, Bolu E, Ozata M, Oktenli C, Sengul A, Inal A, Yersilova Z, Kilciler G, Ozdemir IC, Kocar IH. Gonadotropin treatment restores in vitro interleukin-1 beta and tumor necrosis factor-alpha production by stimulated peripheral blood mononuclear cells from patients with idiopathic hypogonadotropic hypogonadism. Clin Exp Immunol 132:265-270, 2003. 73. Dolu H, Ulas UH, Bolu E, Ozkardes A, Odabasi Z, Ozata M, Vural O Evaluation of central neuropathy in type II diabetes mellitus by multimodal evoked potentials. Acta Neurol Belg. 2003 Dec;103(4):206-11. 74. Oguz Y, Oktenli C, Ozata M, Ozgurtas T, Sanisoglu Y, Yenicesu M, Vural A, Bulucu F, Kocar IH: The midnight-to-morning urinary cortisol increment method is not relia for the assesment of hypothalamic-pituitary-adrenal insufficiency in patients with end-stage kidney disease. J.Endrocrinol Invest, 2003 Jul; 26(7): 609-15 75. Oktenli C, Yesilova Z, Ozata M, Yaman H, Tuzun A, Dundar S, Sanisoglu SY, Musabak U, Erbil MK, Dagalp K.: Gonadotropin treatment increases homocysteine levels in idiopathic hypogonadotrophic hypogonadism: an indirect effect mediated by chang in body composition. J.Endocrinol. 2003 Oct;179 (1):35-9 76. Kirilmaz A, Bolu E, Kilicaslan F, Erinc K, Uzun M, Isik E, Ozata M, Ozdemir C, Demirtas A: Comparison of electrocardiographic repolarization patterns between hypogonad males and normal subjects: Ann Noninvasivi Electrocardiol. 2003 Oct; 8 (4): 284-8. 77. Ataergin S, Arpaci F, Turan M. Ozet A, Yilmaz MI, Ozata M, Ozturk B, Komurcu S, Ulutin C: The effect of leptin on engraftment in patients undergoing peripheral blood stem cell transplantation: Haematologia (Budap). 2003; 32 (4): 389-96. 78. Akar A, Orkunoglu FE, Ozata M, Sengul A, Gur AR. Lack of association between Vitamin D receptor FokI polymorphism and alopecia areata. Eur J Dermatol. 2004 May-Jun;14(3):156-8 79. John K.Park, Ozata M, Lynn P, Chorich, Lili Cheng, Davit P.Bick,Richard J.Sherins, I.C, Ozdemir, Erol Bolu, Joy D. Cogan John A.Philips III and Lawrance: Analysis of th PROP I gene in large cohort of patients with idiopathic hypogonadotrophic hypogonadism. Clinical Endocrinology 60,147-149, 2004 80. Licinio J, Caglayan S, Ozata M, O Yildiz B, Miranda B.de P, O’Kirwan F.O, Wiht by R, Liong L, Cohen, Bhasin S.M., Krauss R, Veldhuis J, Wagner A.J, De Paoli, A.M, Mc Cann M.Mc Wong Ma-Li Wong: Phenotypic effects of leptin replacementon morbid obesity, diabetes mellitus, hypogan adism, and behavior in leptin, deficent adult. PNAS March 30,2004 Vol:101 No:13 4531-4536 81. Z.Yesilova, Ozata M, C.Oktenli, Y.Sanisoglu, M.K.Erbil, K.Dagalp: Effect of supraphysiologic doses of testosterone on fasting plasma total homocysteine concentrations in men with Klinefelter's syndrome Fertility and Sterility. Vol: 81, No: 5 May 2004 S:1278-1282 82. Matochik J.A, Landan ED, Yildiz BO, Ozata M, Caglayan S, De Paoli AM, Wong ML, Licinio J.: Effect of leptin replacement on brain structure in genetically leptin deficient adults. J.Clin Endocrinol Metab.2005 May: 90 (5): 2851-4 83. M.I.Yilmaz, Sonmez A, Kilic S, Celik T, Bingol N, Pinar M, Mumcuoglu T. Ozata M: The association of plasma adiponectin levels with hypertensiven retinopathy. European Journal of Endocrinology 2005; 152; 233-240 84. D.A.Williamson, E.Ravussin, M.L.Wang, A.Wagner, A.D Paoli, Caglayan S, Ozata M, M.Carbin, Walden H, Cheryl A, Licinio J.: Microanalysis of eating behavior of three leptin deficient adults treated with leptin deficient adults treated with leptin therapy: D.A.Williamson et al. Appetite 45, 2005; 75-80 85. E.Funda, Orkunoglu S, Mergen H, Bolu H, Ozata M: Moleculer Scanning for Mutations in the Insulin Receptor Substrate-1 (IRS-1) Gene in Turkish with Type 2 Diabetes Mellitus: Endocrine Journal , 2005, 52 (5) 593-598 86. Bhagavath B, Ozata M, Ozdemir I.C, Bolu E, Bick D.P, Sherins R.J, Layman L.C: The Prevalence of gonadotropin-releasing hormone receptor mutations in a large cohort of patients with hypogonadotropic hypogonadism. Fertil Steril: 2005 Oct.84 (4): 951-7 87. Yesilova Z, Oktenli C, Sanisoglu S.Y, Musabak U, Cakir E, Ozata M, Dagalp K.: Evaluation of insulin sensitivity in patients with Klinefelter’s syndrome: ahyperinsulinemic euglycemic clamp study. Endocrine 2005 Jun: 27(1):11-5 88. Yesilova Z, Ozata M, Oktenli C, Bagci S, Ozcan A, Sanisoglu S.Y, Uygun A, Yaman H, Karaeren N, Dagalp K: Increased acylation stimulating protein concentrations in nonalcoholic fatty liver disease are associated with insulin resistance. Am J.Gastroenterol. 2005 Apr. 100 (4): 842-9 89. Bhagavath B, Podolsky RH, Ozata M, Bolu E, Bick DP, Kulharya A, Sherins RJ, Layman LC Clinical and molecular characterization of a large sample of patients with hypogonadotropic hypogonadism. Fertil Steril. 2006 Mar;85(3):706-13. 90. Karaduman M, Oktenli C, Musabak U, Sengul A, Yesilova Z, Cingoz F, Olgun A, Sanisoglu SY, Baysan O, Yildiz O, Taslipinar A, Tatar H, Kutlu M, Ozata M. Leptin, soluble interleukin-6 receptor, C-reactive protein and soluble vascular cell adhesion molecule-1 levels in human coronary atherosclerotic plaque. Clin Exp Immunol. 2006 Mar;143(3):452-7. 91. Karaduman M, Sengul A, Oktenli C, Pekel A, Yesilova Z, Musabak U, Sanisoglu SY, Gunay C, Baysan O, Kocar IH, Tatar H, Ozata M. Tissue levels of adiponectin, tumour necrosis factor-alpha, soluble intercellular adhesion molecule-1 and heart-type fatty acid-binding protein in human coronaryatherosclerotic plaques. Clin Endocrinol (Oxf). 2006 Feb;64(2):196-202 92. Cerrato F, Shagoury J, Kralickova M, Dwyer A, Falardeau J, Ozata M, Van Vliet G, Bouloux P, Hall JE, Hayes FJ, Pitteloud N, Martin KA, Welt C, Seminara SB. Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism. Eur J Endocrinol. 2006 Nov;155 Suppl 1:S3-S10 93. Mergen H, Karaaslan C, Mergen M, Ozsoy ED, Ozata M. LEPR, ADBR3, IRS-1 and 5-HTT Genes Polymorphisms do not Associate with Obesity. Endocr J. 2006 Nov 24; Feb;54(1):89-94. Epub 2006 Nov 24. 94. Bhagavath B, Xu N, Ozata M, Rosenfield RL, Bick DP, Sherins RJ, Layman LC. KAL1 mutations are not a common cause of idiopathic hypogonadotrophic hypogonadism in humans. Mol Hum Reprod. 2007 Mar;13(3):165-70 95. Licinio J, Milane M, Thakur S, Whelan F, Yildiz BO, Delibasi T, de Miranda PB, Ozata M, Bolu E, Depaoli A, Wong ML. Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight. Appetite. 2007 Apr 6; 96. Caglayan S, Ozata M, Congenital leptin defiency. Obesity and Metabolism, 4:42-58, 2008 97. Kim HG, Kurth I, Lan F, Meliciani I, Wenzel W, Eom SH, Kang GB, Rosenberger G, Tekin M, Ozata M, Bick DP, Sherins RJ, Walker SL, Shi Y, Gusella JF, Layman LC. Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. Am J Hum Genet. 2008 Oct;83(4):511-9. 98. Terekeci HM, Senol MG, Top C, Sahan B, Celik S, Sayan O, Kucukardali Y, Ipcioglu O, Cagiltay E, Oktenli C, Ozata M. Plasma osteoprotegerin concentrations in type 2 diabetic patients and its association with neuropathy. Exp Clin Endocrinol Diabetes. 2009 Mar;117(3):119-23. 99. Erikci AA, Karagoz B, Ozturk A, Caglayan S, Ozisik G, Kaygusuz I, Ozata M. The effect of subclinical hypothyroidism on platelet parameters. Hematology. 2009 Apr;14(2):115-7.
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